Selamectin is best known as the active ingredient found in the medication known as Revolution®. Selamectin is applied topically onto the skin, usually between the shoulder blades of the dog or cat, and has a number of different indications for usage.
Revolution® is formulated with selamectin dosages appropriate for either dogs or cats and available as either Canine Revolution® or Feline Revolution®, in various sizes depending on body weight.
Selamectin kills parasites infecting dogs and cats by stimulating the release of GABA (gamma amino butyric acid) and consequently inhibiting neurotransmission and blocking the stimulation of neurons to cause paralysis.
One of the prime indications for using selamectin, or Revolution®, is as a heartworm preventive medicine for both dogs and cats. When used to prevent heartworms, selamectin needs to be applied monthly.
Selamectin is not effective where adult heartworms are present and is not effective in killing microfilaria (larval heartworms) circulating in the blood stream of dogs and cats infected with heartworms.
Another primary indication for using selamectin is as a flea control medicine for both dogs and cats. As with any flea control product, selamectin is most effective when used as a preventive measure before the dog or cat becomes infested with fleas. However, selamectin will treat an existing flea infestation also. Selamectin should be used monthly for the most effective flea control.
Selamectin also kills ear mites and is therefore an effective ear mite treatment for dogs and cats. One application is often effective in treating ear mites in infected dogs and cats. However, a second dose of selamectin can be applied after one month for stubborn infections.
Selamectin can also be used in dogs to treat:
In cats, selamectin is also known to be secreted into the intestinal tract and can be used to treat hookworm and roundworm infections.
Selamectin is safe for pregnant animals and for nursing female dogs and cats. However, the medicine should not be used in puppies and kittens less than 6 weeks of age and should be used with caution in sick, underweight or debilitated animals. Some Collie breeds may also be sensitive to selamectin toxicity due to a genetic mutation. Caution should be used in these breeds when using selamectin.
Though selamectin is generally safe, side effects have been noted in some cases with its usage. Side effects may include:
Selamectin should be used topically only and should not be administered orally.
Selamectin (Revolution®) is used as a heartworm preventive medicine, a flea control medicine and an ear mite treatment in both dogs and cats and has several other indications as well. It is relatively safe and frequently used in pets. However, as with any medication, the potential for side effects is present and animals should be observed closely after treatment with selamectin.